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GHK-Cu acts on extracellular matrix and broad genomic transcription

CPT: Pharmacometrics & Systems Pharmacology 1(9):e2 Rasmussen BB, Brix TH, Kyvik KO, Brosen K (2002) The interindividual differences in the 3-demthylation of caffeine alias CYP1A2 is determined by both genetic and environmental factors

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Notably, the hydroxyl group at the C4 position of the tetrahydropyran ring of substrate 7 also stabilizes the GSH-thiolate through an additional hydrogen bond (Extended Data Fig

This direct access allows glutathione to work immediately, neutralizing free radicals and supporting detoxification