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Oral glutathione : Supplements have historically faced absorption challenges since the molecule can be broken down in the digestive system

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The arginine salt version is especially valuable for capsule-based research because it is commonly selected for improved stability and suitability in oral-format research models

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At baseline and at weeks 8 and 12, a clinician should assess fasting insulin and HOMA-IR (the homeostasis model assessment of insulin resistance, a calculated index derived from fasting glucose and insulin), HbA1c, high-sensitivity C-reactive protein as an inflammatory marker, and body composition by DEXA scan or bioelectrical impedance

Phase 1/2 trial reported no serious adverse events at doses up to 60 mcg/kg (Teichman et al., J Clin Endocrinol Metab 2006)