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In addition, the number of mitochondria increase from primary spermatocytes to round spermatids, a process that requires iron for mitochondrial ironsulfur clusters and heme synthesis

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In the 16-week add-on to insulin trial, the incidence of reported hypoglycemia was 7.9% with pioglitazone 15 mg, 15.4% with pioglitazone 30 mg and 4.8% with placebo

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This is known as the titration phase