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In the retatrutide phase 2 trial, at 12 mg over 48 weeks, every participant on the highest dose lost at least 5%, 93% lost at least 10%, and 83% lost at least 15%, with roughly two-thirds reaching 20% or more
This made it the third most common side effect after nausea/vomiting and diarrhea
Compounded formulations may include additional inactive ingredients and can differ from the brand
Safety note: It carries a boxed warning for thyroid C-cell tumor risk
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Gastroenterology 2013;145:12711273
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