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The present study adds oxidative stress, as indexed by GSH depletion, as another dimension of thalamic involvement in migraine

The capacity for GSH synthesis is insufficient to maintain GSH concentrations when tissues are exposed to certain drugs or their metabolites (e.g., acetaminophen), redox cycling compounds (e.g., menadione), peroxides (e.g., tertbutyl hydroperoxide), X-rays, or ultraviolet radiation

10.1017/S2045796018000227 76

An important advantage of this therapy is that it does not significantly increase hormones such as cortisol or prolactin, which are often associated with unwanted side effects

It is distributed throughout the central and peripheral nervous system

Available evidence does not establish one glutathione form as universally superior, and recommendations should reflect individual need, formulation quality, tolerance and clinical context