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16 The anti-inflammatory effects of GLP-1 RAs involve the reduction of proinflammatory cytokines such as IL-6 and TNF-

If you want to continue GLP-1 therapy, you'll likely need to switch to a brand-name GLP-1

This reduces long term risk for diabetes and insulin resistance

It may increase the blood-thinning effects of anticoagulants like Warfarin (Coumadin), requiring careful monitoring of prothrombin times and bleeding risks

Short-chain fatty acid acetate triggers antiviral response mediated by RIG-I in cells from infants with respiratory syncytial virus bronchiolitis

Data on the safety and efficacy of such therapies over decades are lacking, creating uncertainty about their role in chronic use, Roberts says