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Hope for boosting GLP-1s half-life in the body came in the 1990s, when endocrinologist John Eng, at the Bronx Veteran Affairs Hospital, noticed something curious about the Gila monster while researching snake and lizard venom effects on the pancreas

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Increase in water reabsorption In a spontaneous hypertensive rat model, TMAO increased plasma osmotic pressure and water reabsorption via the TMAO-AVP-(AQP-2) axis, which contributed to hypertension (121)