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Aukrust P, Mller F, Svardal AM, Ueland T, Berge RK, Frland SS

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Mice with homozygous null mutation for the most abundant glutathione peroxidase, GPx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide

This means the drug formulation, not physiology, can be the rate limiting factor for absorption

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Long non-coding RNA (lncRNA) typically competes with miRNA for binding, thereby regulating the interaction between miRNA and its target mRNA, which in turn affects the expression of key genes involved in ferroptosis