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Stefano GB, Kream RM (2007) Endogenous morphine synthetic pathway preceded and gave rise to catecholamine synthesis in evolution

The GSH/GSSG ratio maintains ~100:1 at steady state but decreases to 10:1 or less under oxidative stress

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Defined onset window Peak plasma at ~1 hour with a 2.7-hour half-life gives a predictable research window without prolonged exposure

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These medications work by mimicking the action of naturally occurring GLP-1 , a hormone released by the intestine in response to food intake