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The migration rate of endothelial cells, an important functional indicator, was found to be accelerated after FOXO4-DRI treatment (Figure 4G)

However, mild side effects such as digestive upset, nausea, and occasional skin reactions may occur, especially when beginning supplementation

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A cause of hereditary hemolytic anemia

Together, these effects could lower systemic inflammatory markers

Commonly reported side effects included: Nausea (the most frequently reported, particularly at higher doses) Vomiting Diarrhoea Decreased appetite Constipation Eructation (belching) At the 12 mg dose, gastrointestinal adverse events were reported in a higher proportion of participants compared with lower doses, though most did not lead to treatment discontinuation