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The liver and mitochondria require adequate antioxidants, minerals, and amino acids to neutralize oxidative byproducts generated by medications, inflammation, and environmental exposures

Alcohol needs contact time to be effective

Avoid exceeding prescribed doses to reduce side effects

2a,b) and reduced subsequent food consumption (Extended Data Fig

Renal impairment defined as estimated creatinine clearance (CLcr) by Cockcroft-Gault equation less than 50 mL/min [see Use in Specific Populations (8.6) and Clinical Pharmacology (12.3)]

For an adult, the maximum recommended single dose of acetaminophen is 1 gram and the maximum dose in a 24-hour period is 4 grams