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Now, an international collaboration between researchers at a number of institutions across China and at the University of Cambridge, UK, has shown that bumetanide is safe to use and effective at reducing symptoms in children as young as three years old

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However, the complete datasets were never fully published, which makes independent evaluation difficult

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Because topical research uses concentration-based dosing rather than absolute-mass dosing, the researcher must formulate the peptide into a carrier base at a target concentration, then apply a consistent volume to the research area