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Calf pain, swelling, or tenderness, particularly one-sided

Clinical trials show triglyceride reductions correlating with weight loss and improved insulin sensitivity, with greater effects typically seen at higher doses

Certain atypical naevi, classified as dysplastic naevi (also called Clark's naevi), may resemble melanoma and may also predispose to melanoma, especially in patients with a strong family history of atypical naevi and melanoma (dysplastic naevus syndrome)

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Garber AJ, Handelsman Y, Grunberger G et al (2020) Consensus statement by the American Association of Clinical Endocrinologists and American College of Endocrinology on the comprehensive type 2 diabetes management algorithm - 2020 executive summary

Start: Begin at 330 mcg total once daily (Standard) to gauge tolerability