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That said, diet alone is unlikely to fully compensate for age-related mitochondrial decline, which is why targeted supplementation, particularly CoQ10, is often recommended alongside dietary optimisation if you're over 35

One study from February 2025, for instance, suggests that people who take glucagon-like peptide-1 receptor agonist medication like Ozempic to treat diabetes have a lower depression risk than peers taking other types of drugs for this metabolic condition

Strategies to minimize side effects include eating smaller, more frequent meals, avoiding high-fat foods, staying well-hydrated, and not lying down immediately after eating

In some cases, counterfeit GLP-1 drugs are illegally marketed as authentic but instead contain harmful or incorrect ingredients, or have too little, too much or no active ingredient at all

Access this article Similar content being viewed by others Abbreviations ALCAR: Acetyl-l-carnitine OCTN2: Organic cation transporter novel 2 CPT I: Carnitine palmitoyltransferase I CPT II: Carnitine palmitoyltransferase II CAT: Carnitine acetyltransferase MRS: Magnetic resonance spectroscopy 13 C-NMR: 13 C-nuclear magnetic resonance spectroscopy OGD: Oxygen-glucose deprivation HI: Hypoxia-ischemia TBI: Traumatic brain injury 3-NPA: 3-nitropropionic acid i.p.: Intraperitoneal CSF: Cerebrospinal fluid mTOR: Mammalian target of rapamycin NGF: Nerve growth factor pNFH: Phosphorylated high-molecular weight neurofilament rCMRglc: Cerebral regional metabolic rate of glucose TBI: Traumatic brain injury TCA: Tricarboxylic acid References Jones LL, McDonald DA, Borum PR (2010) Acylcarnitines: role in brain

Fakhoury, W