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Semaglutide injection and CV impact was evaluated using the SUSTAIN-6 trial (designed as a non-inferiority trials), which primarily showed a reduction in the rate of non-fatal stroke events (RR 0.61
First, a substantial proportion of the mechanistic evidence is derived from animal models and in vitro studies, which may not fully capture the complexity of human liver physiology and disease pathogenesis
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2015;10:e0132376
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