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For hair specifically, the relevant subset of these pathways translates into improved follicle environment, reduced oxidative damage to dermal papilla cells, and a calmer inflammatory state three of the four root causes of androgenetic alopecia, addressed simultaneously by a single molecule

Mechanisms of action Preclinical studies document: Anxiolytic effect without sedation in classical tests (elevated plus maze, open field, light-dark box) GABAergic system modulation : allosteric potentiation of GABA-A observed ex vivo Enkephalin increase (endogenous opioid peptide) and serotonergic modulation Immunomodulatory effects inherited from tuftsin: macrophage activation, T-helper modulation Behavioural models Anxiolysis is measured via time spent in open arms of the elevated plus maze (EPM), visit ratio of central zones of open field , and exit latency in light-dark box

Vitamin B1 is used for treatment of thiamine deficiency, such as, Beriberi and Wernickes Encephalophathy