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Sulfonylureas (such as gliclazide) carry a higher risk of hypoglycaemia than tirzepatide monotherapy, and hypoglycaemia-related headaches may be more frequent with these agents, particularly in elderly patients or those with irregular meal patterns

Semaglutide overdose symptoms include severe nausea, persistent vomiting, abdominal pain, and in serious cases, acute pancreatitis or severe dehydration requiring hospitalization

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