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In clinical studies, two beneficial bacterial species, Bacteroides fragilis, have risen while Lactobacillus and Bifidobacterium have dropped significantly

The cleaner independent support is a 2021 study in APP/PS1 Alzheimer's-model mice (Sun 2021, PMID 34827486), which reported improved Morris water maze performance and increased synaptophysin via PI3K/AKT

These discrepancies in findings across studies may arise from differences in experimental designs, analytical methodologies, and data processing techniques

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