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Clinical studies usually employ 600 to 1,200 mg per day in divided doses

evaluated three antioxidants (N-acetylcysteine, -lipoic acid, vitamin E

Children presenting neurological signs or symptoms, those unable to take oral medication, individuals with known malabsorption syndromes, infants under 6 months old, and patients using medications that may interfere with vitamin B12 absorption are typically treated with a parenteral protocol (1)

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The main molecular mechanisms involved in the modulation of eryptosis studied to date, including intracellular calcium levels, ceramide, ROS, NO, changes in cellular energy metabolism, PS externalization, ion channel regulation, Fas-mediated signaling pathways, kinase-associated, and caspases activation, among others represent potential targets for inducing or inhibiting erythrocyte death

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