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Receptor autophosphorylation, downstream phosphorylation of IRS-1 and Shc, and activation of PI3K and MAPK occur with similar kinetics to native IGF-1 once the ligand reaches the receptor
Some commercial insurance plans cover Wegovy and Zepbound for weight management, but coverage is inconsistent and often requires prior authorization, step therapy, and a documented BMI of 30+ (or 27+ with comorbidities)
They also come with specific instructions around how and when they need to be taken, and they may not fully replace the role of higher-dose injectable treatments for every patient
7 , E67 (2019)
The medications covered under the Bridge program All four medications included in the program are in the GLP-1 family, which means they work by mimicking gut hormones to lower appetite, slow digestion, and regulate blood sugar, but theyre not identical
This is because starting at the full dose invariably causes bad side-effects
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