A more detailed breakdown of the criteria used to define the study population of the LEADER trial, along with our translation and specification, is available in the supplementary material (Table S1)
This aligns with trial design: all major GLP-1 trials, including STEP-1 and SURMOUNT-1, required participants to follow a 500-calorie daily deficit and at least 150 minutes per week of moderate physical activity
I think it would be helpful if there was some kind of acknowledgement that these are people that are living with a disease, and they've taken a treatment for that disease, and there is no shame in that they're improving their overall health. Evers said people need to move away from calling GLP-1 drugs weight-loss medications and instead call them obesity medications, which gives them an accurate medical context
Cytokine 1997
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