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Ohio State notes that GLP-1 medications can lower both appetite for food and thirst for liquids, while Wegovys official side-effect pages specifically mention fatigue as a common side effect

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Change history 16 August 2024 A Correction to this paper has been published: Abbreviations AAV: Adeno-associated viral Ago2: Argonaute 2 Alk: Anaplastic lymphoma kinase APEX: Ascorbate peroxidase APEX-MS: APEX mass spectrometry Arg: Arginine ASY1: ASYNAPTIC 1 ASY3: ASYNAPTIC 3 ATG8: AuTophaGy-related 8 ATG9A: Autophagy-related protein 9A ATG13: Autophagy-related protein 13 ATGs: Autophagy-related proteins BiFC: Bimolecular fluorescence complementation assay BIN2: BRASSINOSTEROID-INSENSITIVE2 BirA: an Escherichia coli biotin protein ligase mutant BP: Biotin-phenol Btn-An: Biotin-phenylamine BV2: Mouse microglial CDPs: Caspase-dependent nonlethal cellular processes CEP97: Centrosomal protein 97 ChIP-seq: Chromatin immunoprecipitation sequencing Co-IP: Co-immunoprecipitation COVID-19: Coronavirus disease 2019 CRIP2: Cysteine-rich protein 2 CRL4CRBN: CUL4-DDB1-CRBN-RBX1 Csw: Corkscrew CTPS: CTP synthase CUL4: Cullin 4 DAB: Detect diaminobenzidine dGBP: Conditionally stable GFP-binding nanobody Dlg1: Discs large 1 EARP: Endosome-associated recycling protein eCRs: Engineered chromatin readers EM: Electron microscopy EndoU: Endoribonuclease ER: Endoplasmic reticulum ErbB2: Human epidermal growth factor receptor 2 ERM: Ezrin-radixin-moesin EV: Empty vector FACS: Fluorescence-activated cell sorting FL-Bid: Full length BH3-interacting domain death agonist FLYWCH1: FLYWCH/Zn-finger DNA-binding domain FKBP: FK506-binding protein FRB: FKBP12-rapamycin-binding GARP: Glycoprotein A repetitions predominant Gly: Glycine GIGYF2: Grb10-interacting GYF protein 2 GST Pull-down Assay: Glutathione S-transferase pull-down assay H3K4me3: Trimethylation of lysine 4 on histone H3 H3K9me3: Trimethylated histone 3 lysine 9 H3K27me3: Tri-methylation at lysine 27 of histone H3 HopF2: HopF2bPt0DC3000 HRD: Hairy root disease HRP: Horseradish peroxidase hTR: Human telomerase RNA IKZF1: IKAROS Family Zinc Finger 1 IMC: Inner membrane complex IMS: Intermembrane space iPSD: Inhibitory postsynaptic density LC-MS/MS: Liquid chromatography-tandem mass spectrometry LMNA: Lamin A MAVS: Mitochondrial antiviral-signaling protein MDM2: Mouse double minute 2 miniSOG: Mini singlet Oxygen Generator MP: Myristoylation/palmitoylation N2A: Mouse neuroblastoma ncMTOCs: Non-centrosomal microtubule-organizing centers NINJA: Novel INteractor of JAZ NLR: Nucleotide-binding leucine-rich repeat NPC: Nuclear pore complex NrCAM: Neuronal Cell Adhesion Molecule Nrg1: Neuregulin 1 Nups: Nucleoporins OMM: Outer Mitochondrial Membrane ORF3a: Open-reading frames 3a PBL: Promiscuous biotin ligase PL: Proximity labeling PLK-1: Polo-like kinase 1 PL-TAP: Proximity labeling and tandem affinity purification PML: Promyelocytic leukemia PML NBs: PROMYELOCYTIC Leukemia Nuclear Bodies POI: Protein of interest PPIs: Protein-protein interactions Pst: Pseudomonas syringae pv

In individuals with obesity, the muscle tissue shows an accumulation of fat and changes in muscle fiber composition, resulting in reduced mobility and performance