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is that they have evolved as a result of a need for a higher regulatory input in Wnt signaling in the adult tissue stem cells frequently seen in long-lived vertebrates (Clevers et al., Lgr5 especially, has garnered much attention the last few years as a high fidelity marker of stem cells in several regenerating tissues (Schuijers and Clevers, 2012)

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Annals of dermatology , 28 (4), 438

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