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BMC Pharmacol Toxicol 15:40, 2014
May 2007;5(5):550-5
*Don't Forget the Sterile Water* - Sold Here *Not Available Outside of the US CJC-1295 NO DAC (MOD GRF 1-29) 50 VIALS AT 30 PERCENT OFF Original price was: $1,612.50.$1,128.75Current price is: $1,128.75.*SAVE $483.75 BY ORDERING IN BULK
Morrow LA, OBrien MB, Moller DE, Flier JS, Moses AC
INTRODUCTION Tirzepatide is a synthetic peptide composed of 39 amino acids, which functions as a dual receptor agonist (RA) binding both the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors and this unique mechanism of action resulted in the nickname twincretin. The structure of tirzepatide is based on that of the native GIP with the addition of a 20-carbon fatty diacid moiety, which increases its half-life to 5 days allowing for once-weekly administration.1 Studies using animal models of obesity and diabetes have shown that the co-administration of GIP and GLP-1 has synergistic effects in reducing body weight, food consumption, and fat mass.1 Tirzepatides dual agonist activity may result in these benefits in humans as well, as evidenced the significant reductions in glycated hemoglobin (HbA1c) levels and body weight in patients with type 2 diabetes mellitus (T2DM) observed in phase 3 clinical trials (such as, SURPASS
It significantly upregulates VEGF (vascular endothelial growth factor) expression, stimulating endothelial cell proliferation and tubule formation
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