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Eight studies did not meet the inclusion criteria of "the study patients are humans"

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Could the authors clarify how controls were selected and whether analyses were adequately adjusted for baseline maternal BMI

N Engl J Med 351(4):327336 Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA (2014) Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials

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Theyve also become subject to countless off-label experiments, including using lower-than-prescribed doses or spacing out injections