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[3] [1] Semaglutide carries a boxed warning about thyroid C-cell tumors observed in rodent studies (though human relevance remains uncertain) and is contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

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c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity

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Zepbound is approved for adults with obesity (BMI 30) or overweight (BMI 27) with at least one weight-related health condition and should be used alongside a reduced-calorie diet and increased physical activity

Semaglutide's longer half-life (7 days vs