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Factors that may contribute to reflux symptoms with semaglutide include: Prolonged gastric retention increasing intragastric pressure Nausea and retching, which can compromise sphincter integrity Changes in eating patterns and meal composition Pre-existing gastroesophageal reflux disease (GERD) that becomes symptomatic Clinical experience and patient reports suggest that some individuals do develop new-onset reflux symptoms or experience worsening of pre-existing GERD after initiating semaglutide therapy

Dosing protocol unless otherwise specified by your doctor is 0.2 ml sub-Q (300mcg) at bedtime five nights a week

Start low and go slow to avoid feeling gassy or more bloated

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What Are Compounded GLP-1 Drugs

But change takes time