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One of the key pieces of evidence BPI includes is a previous patent application from DiMarchi
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This stability allows for safe shipping, but it is not a substitute for proper cold storage for preserving long-term viability
AAV vectors are generally safe at therapeutic doses eight AAV-based gene therapies have been FDA-approved as of 2024 but at high doses, above roughly 10^14 viral genomes per kilogram, the literature documents immune reactions, liver toxicity, and in rare cases, genotoxicity
Hattori, A
