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Alzahrani and colleagues reported in 2025 that intravenous glutathione is associated with serious safety concerns like anaphylaxis and hepatotoxicity. Regulatory bodies have issued clear warnings: Philippine FDA (2025): The FDA has not approved any injectable products for skin lightening UK Trading Standards (June 2025): Public warning about dangerous glutathione IV drips No professional dermatology organization endorses IV glutathione for skin lightening purposes

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BD Biosciences, Woburn, MA, USA) and supplemented with transforming growth factor beta 1 for up to 21 days

When taking melatonin or any new supplement, some people may be more at risk, including: People with an existing heart failure diagnosis Adults older than 65, as age often brings additional health concerns and a higher likelihood of taking multiple medications Individuals with multiple risk factors for heart disease, such as: People in these groups may not only be taking melatonin, but also other supplements or prescription medications