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Avoid injecting directly into the tendon itself, as this can cause additional trauma

The side effect profile at the 12mg dose includes nausea (28% of participants), diarrhea (23%), constipation (17%), and vomiting (12%)

Safety Both GLP-1s and SGLT2 drugs come with the potential for side effects, medication interactions, and other safety precautions and may not be suitable or safe for everyone

GAPDH was used as a loading control ( n = 3).( B ) cAMP levels in coronary effluents were measured at timed intervals during an initial 10-minute perfusion of WT hearts with either 6 nM GLP-1(2836), scrambled(2836) control (Scram), or buffer-only control (Cntl), or with 0.3 nM GLP-1, and were normalized to coronary flow (mL/min/g heart weight)

These findings reinforce the peptides relevance for studies of insulin resistance, beta-cell dynamics, and the broader mechanisms underlying metabolic disease progression