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There are no useful placebo controlled trials in humans for either

Aug 2021;141(8):773-779

Research spanning decades has elucidated the anti-inflammatory properties of KPV and its parent molecule, -MSH, in a diverse array of inflammatory conditions, including fever, dermatitis, vasculitis, arthritis, and gastrointestinal inflammation

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Lack of VITAMIN B12 can create anaemias

Most people just feel a brief sting, very similar to any other standard jab