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(3) GHK-Cu is posited to function as a repair-associated signal that may engage fibroblasts, immune cells, enzymes, ion channels, and cell-surface receptors, with reported downstream potential over gene expression

In contrast, long-acting GLP-1RA has a less pronounced effect on gastric emptying over time due to tachyphylaxis [72] but yields more significant and consistent weight loss [71]

Ndumele, C.E

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GLP-1 (glucagon-like peptide-1) receptor activation slows gastric emptying, reduces appetite through central nervous system signaling, and improves insulin response

Its primary role in this synergy is to increase the amplitude of the GH pulse