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The most common skin, hair and nail changes on GLP-1 drugs While there aren't any hard-and-fast numbers on how many people experience skin changes as a result of using GLP-1s yet, the AAD does affirm that "GLP-1 drugs can have significant impacts on your skin." The organization lists the following as known consequences and the dermatologists we spoke to say they're seeing them in their offices: There aren't yet any hard-and-fast numbers on how many people experience appearance-related changes while taking GLP-1 medications

and weekly changes in fat mass ( G ) and lean mass ( H ) after semaglutide therapy

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