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Astrocytes are neural parenchymal cells that proliferate after injury to replace lost neural tissue, form borders, and protect and preserve neural parenchyma in different disorder contexts as discussed in multiple places in this article

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Abbreviations ABC: ATP-binding cassette ABCG2: ATP-binding cassette subfamily G member 2 ADCC: Antibody-dependent cell-mediated cytotoxicity AGGF1: G-patch and FHA domains 1 ANGPT-2: Angiopoietin-2 ATGs: Autophagy-related genes ATM: Ataxia-telangiectasia mutated BER: Base excision repair BIRC5: Baculoviral inhibitor of apoptosis repeat containing 5 CAFs: Cancer-associated fibroblasts CD44s: CD44 subtype CHK1: Checkpoint kinase 1 CMA: Chaperone-mediated autophagy CSCs: Cancer stem cells CTL: Cytotoxic T lymphocyte CXCL-12: Chemokine C-X-C motif ligand-12 CXCR4: C-X-C Chemokine Receptor Type 4 DC: Dendritic cell DDR: DNA damage response DSB: Double strand breaks ECM: Extracellular matrix EGFL7: EGF-like domain 7 EMT: Epithelial-mesenchymal transition EMT-TFs: Transcription factors associated with epithelial-mesenchymal transition ENO: Enolase ER: Estrogen receptor ETC: Electron transport chain 5-FU: 5-fluorouracil FoxP3: Forkhead box P3 GLUT: Glucose transporter GPR49: G-Protein Coupled Receptor 49 GPR67: G-Protein Coupled Receptor 67 GSCs: Glioblastoma stem cells HCAM: Homing Cell Adhesion Molecule HIFs: Hypoxia-inducible factors HK: Hexokinase HNSCC: Head and neck squamous cell carcinoma HR: Homologous recombination HREs: Hypoxia response elements IAPs: Inhibitors of apoptosis family proteins ICP: Immune checkpoints ICPI: Immune checkpoint inhibitors ICPLs: The ligands of immune checkpoints JAK: Janus Kinase KLF5: Krppel-like factor 5 LDH: Lactate dehydrogenase lncRNAs: Long non-coding RNAs MACC1: Metastasis-associated colon cancer 1 MDR: Multidrug resistance MDSCs: Myeloid-derived suppressor cells MHC-I: Major histocompatibility complex class I MRN: MRE11-RAD50-NBS1 MRP1: Multidrug resistance-associated protein 1 MSCs: Mesenchymal stem cells NER: Nucleotide excision repair NHEJ: Non-homologous end joining NK: Natural kill OCT4: Octamer-binding transcription factor 4 OXPHOS: Oxygen-dependent mitochondrial oxidative phosphorylation PDH: Pyruvate dehydrogenase PDK1: Pyruvate dehydrogenase kinase 1 PFKFB: 6-fructose-2-phosphate kinase PGF: Placenta growth factor PGK1: Phosphoglycerol kinase 1 Pgp-1: Phagocytic Glycoprotein-1 PHGDH: Phosphoglycerate dehydrogenase PK: Pyruvate kinase PKM2: M2 pyruvate kinase PRR: Post-replication repair ROS: Reactive oxygen species SCF: Stem cell factor SOCS1: Suppressor of cytokine signaling 1 SOD2: Superoxide dismutase 2 SOX2: SRY-box 2 STAT3: Signal transducer and activator of transcription 3 TAMs: Tumor-associated macrophages TCA: Tricarboxylic acid TCR: T cell receptor TILs: Tumor-infiltrating lymphocytes TME: Tumor microenvironment Treg cells: Regulatory T cells ULBP: UL16-binding protein VEGF: Vascular endothelial growth factor VHL: Von Hippel-Lindau References Bray Fea

Stem Cells 28 , 10191029 (2010)

doi: 10.3389/fphys.2018.01600 24 WanTSunHMaoZZhangLChenXShiYet al

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