oral semaglutide versus subcutaneous semaglutide Dose-equivalence reference based on pivotal GLP-1/dual-agonist trials: SURMOUNT-1 (tirzepatide/Zepbound, 72 weeks) STEP-1 (subcutaneous semaglutide/Wegovy, 68 weeks) OASIS-4 (oral semaglutide/Wegovy, 64 weeks). For educational comparison only—these are semaglutide and liraglutide difference between

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doi: 10.1177/0956797619826970 60 KanayamaGHudsonJIPopeHGJr

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Benefits Extensive clinical research Well-established safety profile FDA approved for chronic weight management Effective appetite reduction Weekly dosing Semaglutide remains an excellent first-line option for many patients beginning medical weight loss