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(If you prefer to watch, rather than read, a video version of this letter can be found at the end) New Paper

It is plausible, though untested, that targeted modulation of GLP-1R activity could maximize the beneficial effects of GLP-1 while minimizing potential adverse effects, particularly in conditions involving metabolic dysfunction, cardiovascular health, or other age-associated pathologies

we continued follow-up after changes in medication for an extra 2 years or until death or emigration, whichever came first

Steinmetz, J

It targets both the GLP-1 receptor and the GIP receptor, which is glucose-dependent insulinotropic polypeptide

Clinical trials have shown that you can lose approximately 2% of your body weight in one month