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Shah VN, Akturk HK, Kruger D, Ahmann A, Bhargava A, Bakoyannis G, et al

Patients receive full informed consent before any treatment

Notably, even surgery often has higher failure rates in EDS due to fragile tissues and impaired healing

the rest is mechanistic reasoning that a clinician should weigh individually: Known copper or peptide allergy the most concrete contraindication, explicit enough that clinical researchers screen it out (NCT07437586)

You may benefit from a longer initial treatment course, a more gradual taper, or a commitment to maintenance dosing rather than complete discontinuation

Primary outcomes Compared to SGLT2i monotherapy, combination therapy with SGLT2i and GLP-1RA was associated with a lower risk of the primary composite outcome (HR, 0.87