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The hypoglycaemia risk is primarily with insulin or sulphonylureas, as GLP-1 receptor agonists alone rarely cause hypoglycaemia

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Routes that Bypass First-Pass Metabolism: Sublingual (e.g., nitroglycerin) Intravenous (IV) Rectal (partial) Transdermal patches Clinical Significance: Important when dosing oral medications to achieve therapeutic effect

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Dosing Frequency and Schedule The difference between taking a medication once weekly versus once daily significantly affects adherence patterns