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Unlike earlier agents such as semaglutide (a GLP-1 receptor agonist) or tirzepatide (a dual GIP and GLP-1 receptor agonist), retatrutide simultaneously activates three distinct hormone receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors
Most manufacturers state that a pen must be discarded 56 days (eight weeks) after the first use, even if there is medication left
It mimics a natural hormone that regulates blood sugar and satiety, helping patients eat less and lose weight
Most weight loss data comes from studies of phentermine plus topiramate (Qsymia), which showed greater weight reduction than either agent alone in obese patients
As you become comfortable with basic movements, progressively increase the challenge
L., & Stephens, F
