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activation of presynaptic 2 receptors in the brainstem reduces sympathetic outflow , lowering blood pressure (see clonidine) methyldopa's effect also produce a reduction of plasma renin levels, which contributes to its antihypertensive effects Figure 1
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The experiments were conducted in Peltz's laboratory at Roche Palo Alto in Palo Alto, Calif., where Peltz worked before coming to Stanford in July 2008
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