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Large cardiovascular outcome trials have also demonstrated that several GLP-1 agents reduce major adverse cardiovascular events

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did not observe alterations in total cholesterol, HDL fraction, and triacylglycerol levels in T1DM rats after treatment with Vildagliptin 36

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A recent meta-analysis of mixed evidence (5 RCTs 52,183,184,185,186 and 1 cohort study 187 ) in 2,071 people with T2DM or Parkinsons disease suggested antidepressant efficacy of the GLP-1RAs exenatide and liraglutide over 2452 weeks 188