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In particular, exendin-4 was discovered in the secretions of the venom glands of the Arizona gila monster (Heloderma suspectum), which actively interacts with human GLP-1 receptors while being resistant to the action of DPP-4 (see Figure 2)

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Formulators often combine the core pentadecapeptide with organic arginine salts to form stable molecular complexes

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