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129 131 Cyclosporine was found to inhibit CYP3A4 with a K i of 1.42 M in human liver microsomes, and systemic exposure of atorvastatin increased 15-fold in humans with the co-administration of cyclosporine

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However, rate-limiting signalling bottlenecks and negative feedback associated with more distal steps in the pathways have diminished the ability of otherwise promising interventions to mimic or enhance early steps in the insulin signalling pathways

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