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On the scrutiny side: the absence of a published ingredient list is the most significant limitation for any buyer trying to make an informed decision

E., Amato, A., Bozzolo, H., Hollway, J., Cook, A., Ramadan, Y., Crowl, L., Zhang, D., Thompson, S., Testa, G., Kliewer, V., Wigal, T., McBurnett, K., and Manos, M

(2000): Noradrenaline, dopamine, serotonin: different effects of psychological stress on brain biogenic amines in mice and rats

The tannin is typical in people with darker skin and can be permanent, although rare