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These processes play key roles to promote chemoresistance in tumors, where elevated GSH inactivates electrophilic chemotherapeutic agents (cisplatin, alkylators), GSTs enable drug conjugation, and MRP-catalyzed efflux reduces intracellular drug levels - while inhibiting therapy-induced oxidative stress at the same time

PMID: 40268366, DOI: 10.1016/j.jacc.2025.03.509

Tirzepatide (Zepbound) is now FDA-approved for moderate-to-severe obstructive sleep apnea (OSA) in adults with obesity

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This practice is carried out with careful consideration, ensuring a thorough medical evaluation to assess factors such as overall health, weight loss history, and potential risks