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A very serious allergic reaction to this drug is rare
Key drivers of clinical benefits Applying each of the differences in HbA1c, blood pressure, serum lipids, BMI and hypoglycemia in turn indicated that change in HbA1c was the biggest driver of clinical benefits for oral semaglutide versus empagliflozin, and change in BMI was the biggest driver of clinical benefits for oral semaglutide versus dulaglutide, with quality-adjusted life expectancy improvements of 0.09 and 0.02 QALYs, respectively, when only these differences between the treatment arms were applied
Understanding these differences underscores the importance of accurate dosing
At the same time, the equity questions are just as important as the efficacy curves: Who will actually have access to orforglipron once it is approved
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