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While H3K4 trimethylation was reduced at many of the key target genes previously highlighted (Figure 4H), some genes showed increased H3K4 trimethylation ( Online Supplementary Figure S6C )

To reconcile these conflicting results, we prepared N-terminally constrained analogues of glucagon-like peptide 1 (GLP-1) and exendin-4 and evaluated their receptor affinity and functionality in vitro

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Focus on easily digestible, nutrient-dense carbohydrate sources such as white rice, pasta, bananas, oats, and white potatoes, which are generally better tolerated than high-fibre options that may exacerbate feelings of fullness