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Serious (less common, require medical attention) Pancreatitis Discontinue immediately if persistent severe abdominal pain occurs, particularly if it radiates to the back Gallbladder disease Rapid weight loss from any cause increases gallstone formation risk Acute kidney injury Primarily secondary to dehydration from vomiting and diarrhoea Hypoglycaemia More likely when semaglutide is combined with other glucose-lowering medications, particularly sulfonylureas or insulin Allergic reactions Discontinue and seek medical attention for swelling, difficulty breathing, or severe rash Drug Interactions What Pharmacists Check Before Dispensing Semaglutides mechanism of slowing gastric emptying creates a pharmacokinetic interaction with any oral medication whose absorption depends on gastric transit time

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