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Fig.3 Proportion of patients achieving MASH resolution without worsening of fibrosis with tirzepatide [6] While GLP-1 RAs are proving effective in treating MASH, their lack of direct action on liver tissue could limit their effectiveness in patients with advanced liver fibrosis or cirrhosis

PMID 21663380

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However, many patients use GLP-1 as a tool to build healthier habits, improve metabolic markers, and create sustainable routines

35 Within the kidneys, there are 2 salient SGLTs: SGLT-1 and SGLT-2