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Safer GLP-1 Alternatives for Patients With Gastroparesis If you have gastroparesis and wish to pursue GLP-1-based weight loss, single-agent semaglutide (a GLP-1 receptor agonist without GIP activation) may carry lower risk than tirzepatide
It also helps maintain healthy blood glucose levels already in the normal range
Given that obesity and adiposity embed an obesogenic epigenetic memory and are linked to accelerated epigenetic aging 8,9,10 , there is growing interest in whether semaglutides metabolic effects might slow or reverse aspects of biological aging
Obesity pharmacotherapy is a rapidly moving field and further research on long-term clinical efficacy, safety and cost-effectiveness will inform better their place in the treatment algorithms for obesity and obesity-related complications over the next years
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A confirmed diagnosis of type 2 diabetes mellitus
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